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Feedback on the successful deployment of Modul-Bio software for the CryoStem national cohort

Since 2012, the national cohort CryoStem, dedicated to the complications of allogeneic hematopoietic stem cell transplantation and particularly Graft versus Host Disease, has been using the MBioLIMS BioBanking® software from Modul-Bio to manage its valuable patients and samples.

130,000 tubes


23 BRC


3,500 patients


1,500 donors

Given the network's success, next September CryoStem will begin studying all complications of allogeneic hematopoietic stem cell transplantation and include unrelated donors, announcing a significant increase in the number of samples taken and therefore stored. To integrate the project's new features, Modul-Bio has thus developed an appropriate upgrade of the software's interface, which will be operational soon.

What is GvHD?

GvHD is one of the main complications of allogeneic hematopoietic stem cell transplantation where the transplanted immune cells from the graft attack the host's cells. There are two types of GvHD, the acute form that occurs within the first 100 days after transplantation and the chronic form which occurs after 100 days. GvHD can cause severe, potentially life-threatening complications immediately after the transplantation, but also longer term, impairing patients' quality of life.

GvHD is a little known disease, with no major therapeutic advances for several years due to the small number of cases per centre which limits the scope of research projects.
CryoStem aims to collect a significant number of biological samples from pre- and post-transplant donor/recipient pairs and make them available for large-scale research projects in order to better understand this rare disease. The CryoStem project works to quality standards to obtain patients' samples and relies on Modul-Bio's expertise to deploy MBioLIMS BioBanking® to manage all the information and samples in a centralised system. This adapted software solution contributed to the network's successful ISO 9001 certification.

MBioLIMS BioBanking® software

Offering web access and multi-site data management, MBioLIMS BioBanking® software is specially designed for BRC and large-scale projects such as national cohorts.

For the GvHD study, the MBioLIMS BioBanking® solution allows the 23 Biological Resource Centres to be connected to a centralised database. The application manages all the cohort's biological samples and their related data.

The software also allows participant centres to work in an independent and standardised manner (barcode labelling systems, reagents, harmonised SOP, information sharing, etc.). The centres can share relevant information while applying high quality standards. Samples are taken at specific times before and after the transplant for acute and chronic forms of GvHD. Centre managers are notified by e-mail at given intervals to prepare the patient sample collection. The software's Reporting module provides precise statistical reports about both patients and samples for subsequent analysis and decision-making.

About CryoStem

The CryoStem national cohort is a national collaborative network aiming to better understand the complications of allotransplant (performed to treat blood diseases) including Graft versus Host Disease (GvHD), to speed up the discovery of biomarkers and the development of adequate treatments. With more than €5.5 million in public funding and support from patients' associations, CryoStem includes 23 Biological Resource Centres (BRC) and 33 of the 36 French transplant units.